The available database comprises research projects in Fisheries, Aquaculture and Seafood Processing active in the time period 2003-2013.
COFASP is an ERA-NET created to directly address actions envisaged within fisheries, aquaculture and seafood. It was created under the KBBE theme in FP7, and is part of the Europe 2020 strategy, which recognises bioeconomy as an important part of the strategy.

More information on the Cofasp project and participating funding organizations is available on the Cofasp website: www.cofasp.eu

Last Update: 2018/01/10

NA
Aquaculture
Activation of immune mechanisms in Atlantic salmon (Salmo salar L.) by CpG oligonucleotides
National
National
Jorunn B. Jørgensen
jorunn.jorgensen@uit.no
UiT - Arctic University of Norway (Norway)
NA - Not available (Not available)
2006
2009
€ NA
NA
Viral diseases cause severe problems for the aquaculture industry and development of efficient virus vaccines is a priority target. Cellular defence mechanisms, both innate and acquired, are especially important to combat viral infections. Therefore ident ification of adjuvants which promote stable induction of Th1 immunity, combined with minimal side effects, is requested. Unmethylated CpG oligodinucleotides (ODNs) within specific flanking bases are relatively abundant in bacterial DNA and are known to st imulate innate immune responses. CpG ODNs show promise as vaccine adjuvant in animal models, and are shown to give less side effects compared to other adjuvants. Studies by our group have shown that certain CpG ODNs induce cytokine expression, stimulate c ell proliferation and induce protection against IPN virus in Atlantic salmon. The innate immune system has evolved the ability to recognize CpG motifs in bacterial DNA via the Toll-like receptor (TLR) 9. In fish, the molecular mechanisms of pathogen-stimu lated TLR-mediated responses are largely unknown. Work by our group and others have demonstrated that fish leucocytes are activated by CpG DNA, indicating the existence of a TLR9 ortholog in salmon. The aim of this project is to clone full-length TLR9 gen e ortholog(s) in salmon, and to study function of CpG-stimulated innate immunity in fish. Knowledge about the various processes explaining how the immune system becomes activated by TLRs will be addressed.
Disease; Fish; Genetic; Salmon;
Not associated to marine areas
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